Endocrine Abstracts

Introduction: Cytokine TNF-alpha has widespread metabolic actions, including induction of insulin resistance, lipolysis and cachexia. Systemic TNF-alpha administration, however, generates complex hormonal and metabolic scenario. No studies employing regional, placebo controlled TNF-alpha infusion exist. Our study was designed to test the hypothesis that local leg perfusion with TNF-alpha directly induces insulin resistance, lipolysis and protein breakdown.<p class="abstext...